Tunable Toxicity of Bufadienolides is Regulated through a Configuration Inversion Catalyzed by a Short‐Chain Dehydrogenase/Reductase

Bufadienolides are toxic components widely found in amphibious toads that exhibit a wide range of biological activities. Guided by UPLC‐QTOF‐MS analysis, several 3‐epi‐bufadienolides with unique structures were isolated from the bile of the Asiatic toad, Bufo gargarizans. However, the enzymatic mach...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Ge, Huang, Weihuan, Chen, Zeping, Zhong, Hao, Zhong, Junhao, Guo, Xiaoxin, Huang, Yuheng, Kandalai, Shruthi, Zhou, Xiaozhuang, Zhang, Nan, Zhou, Yang, Zheng, Qingfei, Tian, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828183/
https://www.ncbi.nlm.nih.gov/pubmed/36125775
http://dx.doi.org/10.1002/cbic.202200473

Ejemplares similares

Ejemplares similares