Direct Observation of “Elongated” Conformational States in α‐Synuclein upon Liquid‐Liquid Phase Separation

α‐Synuclein (α‐syn) is an intrinsically disordered protein (IDP) that undergoes liquid‐liquid phase separation (LLPS), fibrillation, and forms insoluble intracellular Lewy bodies in neurons, which are the hallmark of Parkinson's Disease (PD). Neurotoxicity precedes the formation of aggregates a...

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Detalles Bibliográficos
Autores principales: Ubbiali, Daniele, Fratini, Marta, Piersimoni, Lolita, Ihling, Christian H., Kipping, Marc, Heilmann, Ingo, Iacobucci, Claudio, Sinz, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828221/
https://www.ncbi.nlm.nih.gov/pubmed/36115020
http://dx.doi.org/10.1002/anie.202205726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828221/
https://www.ncbi.nlm.nih.gov/pubmed/36115020
http://dx.doi.org/10.1002/anie.202205726

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