The cation-π interaction in cysteine-rich domain of Smoothened is critical for its cholesterylation and function: The cation-π interaction is required for SMO cholesterylation

The Hedgehog (Hh) signaling pathway is critical for embryonic development and tissue renewal. The G protein-coupled receptor (GPCR)-like protein Smoothened (SMO) is the central signal transducer in the Hh pathway. Cholesterol binds and then covalently links to the D95 residue of cysteine-rich domain...

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Detalles Bibliográficos
Autores principales: Kong, Zekai, Xu, Min, Zhang, Yanqing, Huang, Wenda, Zhao, Xiaolu, Luo, Jie, Song, Bao-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828284/
https://www.ncbi.nlm.nih.gov/pubmed/35904215
http://dx.doi.org/10.3724/abbs.2022090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828284/
https://www.ncbi.nlm.nih.gov/pubmed/35904215
http://dx.doi.org/10.3724/abbs.2022090

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