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The cation-π interaction in cysteine-rich domain of Smoothened is critical for its cholesterylation and function: The cation-π interaction is required for SMO cholesterylation
The Hedgehog (Hh) signaling pathway is critical for embryonic development and tissue renewal. The G protein-coupled receptor (GPCR)-like protein Smoothened (SMO) is the central signal transducer in the Hh pathway. Cholesterol binds and then covalently links to the D95 residue of cysteine-rich domain...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828284/ https://www.ncbi.nlm.nih.gov/pubmed/35904215 http://dx.doi.org/10.3724/abbs.2022090 |