Gemcitabine alters sialic acid binding of the glycocalyx and induces inflammatory cytokine production in cultured endothelial cells

Gemcitabine (GEM) is an anticancer drug inhibiting DNA synthesis. Glomerular thrombotic microangiopathy (TMA) has been reported as an adverse effect. However, the precise mechanism of GEM-induced endothelial injury remains unknown. Cultured human umbilical vein endothelial cells (HUVECs) in the conf...

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Detalles Bibliográficos
Autores principales: Gunji, Mariko, Sawa, Chika, Akiyama, Minako, Mukai, Shumpei, Takaki, Takashi, Kang, Dedong, Honda, Kazuho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828377/
https://www.ncbi.nlm.nih.gov/pubmed/36622466
http://dx.doi.org/10.1007/s00795-022-00347-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828377/
https://www.ncbi.nlm.nih.gov/pubmed/36622466
http://dx.doi.org/10.1007/s00795-022-00347-4

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