FRET Monitoring of a Nonribosomal Peptide Synthetase Elongation Module Reveals Carrier Protein Shuttling between Catalytic Domains

Nonribosomal peptide synthetases (NRPSs) employ multiple domains, specifically arranged in modules, for the assembly‐line biosynthesis of a plethora of bioactive peptides. It is poorly understood how catalysis is correlated with the domain interplay and associated conformational changes. We develope...

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Detalles Bibliográficos
Autores principales: Rüschenbaum, Jennifer, Steinchen, Wieland, Mayerthaler, Florian, Feldberg, Anna‐Lena, Mootz, Henning D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828546/
https://www.ncbi.nlm.nih.gov/pubmed/36169151
http://dx.doi.org/10.1002/anie.202212994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828546/
https://www.ncbi.nlm.nih.gov/pubmed/36169151
http://dx.doi.org/10.1002/anie.202212994

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