Evidence for a fragile X messenger ribonucleoprotein 1 (FMR1) mRNA gain‐of‐function toxicity mechanism contributing to the pathogenesis of fragile X‐associated premature ovarian insufficiency

Fragile X‐associated premature ovarian insufficiency (FXPOI) is among a family of disorders caused by expansion of a CGG trinucleotide repeat sequence located in the 5′ untranslated region (UTR) of the fragile X messenger ribonucleoprotein 1 (FMR1) gene on the X chromosome. Women with FXPOI have a d...

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Detalles Bibliográficos
Autores principales: Rosario, Roseanne, Stewart, Hazel L., Choudhury, Nila Roy, Michlewski, Gracjan, Charlet‐Berguerand, Nicholas, Anderson, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828574/
https://www.ncbi.nlm.nih.gov/pubmed/36250920
http://dx.doi.org/10.1096/fj.202200468RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828574/
https://www.ncbi.nlm.nih.gov/pubmed/36250920
http://dx.doi.org/10.1096/fj.202200468RR

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