The Essential Role of Water Molecules in the Reaction Mechanism of Protein O‐Fucosyltransferase 2

Protein O‐fucosyltransferase 2 (PoFUT2) is an inverting glycosyltransferase (GT) that fucosylates thrombospondin repeats (TSRs) from group 1 and 2. PoFUT2 recognizes a large and diverse number of TSRs through a dynamic network of water‐mediated interactions. By X‐ray structural studies of C. elegans...

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Detalles Bibliográficos
Autores principales: Sanz‐Martínez, Ignacio, García‐García, Ana, Tejero, Tomás, Hurtado‐Guerrero, Ramón, Merino, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828666/
https://www.ncbi.nlm.nih.gov/pubmed/36260536
http://dx.doi.org/10.1002/anie.202213610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828666/
https://www.ncbi.nlm.nih.gov/pubmed/36260536
http://dx.doi.org/10.1002/anie.202213610

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