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4′‐SCF(3)‐Labeling Constitutes a Sensitive (19)F NMR Probe for Characterization of Interactions in the Minor Groove of DNA
Fluorinated nucleotides are invaluable for (19)F NMR studies of nucleic acid structure and function. Here, we synthesized 4′‐SCF(3)‐thymidine (T [Formula: see text] ) and incorporated it into DNA by means of solid‐phase DNA synthesis. NMR studies showed that the 4′‐SCF(3) group exhibited a flexible...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828712/ https://www.ncbi.nlm.nih.gov/pubmed/36163470 http://dx.doi.org/10.1002/anie.202201848 |