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4′‐SCF(3)‐Labeling Constitutes a Sensitive (19)F NMR Probe for Characterization of Interactions in the Minor Groove of DNA

Fluorinated nucleotides are invaluable for (19)F NMR studies of nucleic acid structure and function. Here, we synthesized 4′‐SCF(3)‐thymidine (T [Formula: see text] ) and incorporated it into DNA by means of solid‐phase DNA synthesis. NMR studies showed that the 4′‐SCF(3) group exhibited a flexible...

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Detalles Bibliográficos
Autores principales:	Li, Qiang, Trajkovski, Marko, Fan, Chaochao, Chen, Jialiang, Zhou, Yifei, Lu, Kuan, Li, Hongjun, Su, Xuncheng, Xi, Zhen, Plavec, Janez, Zhou, Chuanzheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828712/ https://www.ncbi.nlm.nih.gov/pubmed/36163470 http://dx.doi.org/10.1002/anie.202201848

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