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pH Dependence of Amyloid‐β Fibril Assembly Kinetics: Unravelling the Microscopic Molecular Processes
Central to Alzheimer's disease (AD) is the assembly of the amyloid‐beta peptide (Aβ) into fibrils. A reduction in pH accompanying inflammation or subcellular compartments, may accelerate fibril formation as the pH approaches Aβ’s isoelectric point (pI). Using global fitting of fibril formation...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828734/ https://www.ncbi.nlm.nih.gov/pubmed/36197009 http://dx.doi.org/10.1002/anie.202210675 |