The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease

The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and α-synuclein pathology in Alzheimer’s disease (AD) and Parkinson’s disease (PD), respectively. The onset of these pathologies coincides with loss of noradrenergic fibers in LC target regions and the emergence of prodromal s...

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Detalles Bibliográficos
Autores principales: Iannitelli, Alexa F., Kelberman, Michael A., Lustberg, Daniel J., Korukonda, Anu, McCann, Katharine E., Mulvey, Bernard, Segal, Arielle, Liles, L. Cameron, Sloan, Steven A., Dougherty, Joseph D., Weinshenker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829100/
https://www.ncbi.nlm.nih.gov/pubmed/36635251
http://dx.doi.org/10.1523/ENEURO.0483-22.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829100/
https://www.ncbi.nlm.nih.gov/pubmed/36635251
http://dx.doi.org/10.1523/ENEURO.0483-22.2022

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