The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions

Expansion of structure-forming CAG/CTG repetitive sequences is the cause of several neurodegenerative disorders and deletion of repeats is a potential therapeutic strategy. Transcription-associated mechanisms are known to cause CAG repeat instability. In this study, we discovered that Thp2, an RNA e...

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Detalles Bibliográficos
Autores principales: Brown, Rebecca E., Su, Xiaofeng A., Fair, Stacey, Wu, Katherine, Verra, Lauren, Jong, Robyn, Andrykovich, Kristin, Freudenreich, Catherine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829180/
https://www.ncbi.nlm.nih.gov/pubmed/36574440
http://dx.doi.org/10.1371/journal.pbio.3001940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829180/
https://www.ncbi.nlm.nih.gov/pubmed/36574440
http://dx.doi.org/10.1371/journal.pbio.3001940

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