Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles

The cilium acts as an antenna receiving and sending signals, the latter via extracellular vesicles (EVs). In C. elegans and mammals, the Autosomal Dominant Polycystic Kidney Disease (ADPKD) gene products polycystin-1 (PC1) and polycystin-2 (PC2) localize to both cilia and EVs, act in the same geneti...

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Detalles Bibliográficos
Autores principales: Walsh, Jonathon D., Wang, Juan, DeHart, Molly, Nikonorova, Inna A., Srinivasan, Jagan, Barr, Maureen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829181/
https://www.ncbi.nlm.nih.gov/pubmed/36574451
http://dx.doi.org/10.1371/journal.pgen.1010560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829181/
https://www.ncbi.nlm.nih.gov/pubmed/36574451
http://dx.doi.org/10.1371/journal.pgen.1010560

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