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Eliminating host-guest incompatibility via enzyme mining enables the high-temperature production of N-acetylglucosamine
The host-guest incompatibility between a production host and non-native enzymes has posed an arduous challenge for synthetic biology, particularly between mesophile-derived enzymes and a thermophilic chassis. In the present study, we develop a thermophilic enzyme mining strategy comprising an automa...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829697/ https://www.ncbi.nlm.nih.gov/pubmed/36636338 http://dx.doi.org/10.1016/j.isci.2022.105774 |