Fluorescence and phosphorescence lifetime imaging reveals a significant cell nuclear viscosity and refractive index changes upon DNA damage

Cytoplasmic viscosity is a crucial parameter in determining rates of diffusion-limited reactions. Changes in viscosity are associated with several diseases, whilst nuclear viscosity determines gene integrity, regulation and expression. Yet how drugs including DNA-damaging agents affect viscosity is...

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Detalles Bibliográficos
Autores principales: Clancy, Ellen, Ramadurai, Siva, Needham, Sarah R., Baker, Karen, Eastwood, Tara A., Weinstein, Julia A., Mulvihill, Daniel P., Botchway, Stanley W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829731/
https://www.ncbi.nlm.nih.gov/pubmed/36624137
http://dx.doi.org/10.1038/s41598-022-26880-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829731/
https://www.ncbi.nlm.nih.gov/pubmed/36624137
http://dx.doi.org/10.1038/s41598-022-26880-x

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