Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer’s disease prediction

Alzheimer’s disease (AD) is the most common late-onset neurodegenerative disorder. Identifying individuals at increased risk of developing AD is important for early intervention. Using data from the Alzheimer Disease Genetics Consortium, we constructed polygenic risk scores (PRSs) for AD and age-at-...

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Detalles Bibliográficos
Autores principales: Gao, Xiaoyi Raymond, Chiariglione, Marion, Qin, Ke, Nuytemans, Karen, Scharre, Douglas W., Li, Yi-Ju, Martin, Eden R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829871/
https://www.ncbi.nlm.nih.gov/pubmed/36624143
http://dx.doi.org/10.1038/s41598-023-27551-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829871/
https://www.ncbi.nlm.nih.gov/pubmed/36624143
http://dx.doi.org/10.1038/s41598-023-27551-1

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