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Polysorbate 80 blocked a peripheral sodium channel, Na(v)1.7, and reduced neuronal excitability

Polysorbate 80 is a non-ionic detergent derived from polyethoxylated sorbitan and oleic acid. It is widely used in pharmaceuticals, foods, and cosmetics as an emulsifier. Na(v)1.7 is a peripheral sodium channel that is highly expressed in sympathetic and sensory neurons, and it plays a critical role...

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Detalles Bibliográficos
Autores principales: Kim, Ryeong-Eun, Choi, Jin-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829885/
https://www.ncbi.nlm.nih.gov/pubmed/36550597
http://dx.doi.org/10.1177/17448069221150138