Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer

IRE1α-XBP1 signaling is emerging as a central orchestrator of malignant progression and immunosuppression in various cancer types. Employing a computational XBP1s detection method applied to TCGA datasets, we demonstrate that expression of the XBP1s mRNA isoform predicts poor survival in non-small c...

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Detalles Bibliográficos
Autores principales: Crowley, Michael J. P., Bhinder, Bhavneet, Markowitz, Geoffrey J., Martin, Mitchell, Verma, Akanksha, Sandoval, Tito A., Chae, Chang-Suk, Yomtoubian, Shira, Hu, Yang, Chopra, Sahil, Tavarez, Diamile A., Giovanelli, Paolo, Gao, Dingcheng, McGraw, Timothy E., Altorki, Nasser K., Elemento, Olivier, Cubillos-Ruiz, Juan R., Mittal, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829901/
https://www.ncbi.nlm.nih.gov/pubmed/36624093
http://dx.doi.org/10.1038/s41467-022-35584-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829901/
https://www.ncbi.nlm.nih.gov/pubmed/36624093
http://dx.doi.org/10.1038/s41467-022-35584-9

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