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Jejunum-derived NF-κB reporter organoids as 3D models for the study of TNF-alpha-induced inflammation

Inflammation is an important process for epithelial barrier protection but when uncontrolled, it can also lead to tissue damage. The nuclear factor-kappa light chain enhancer of activated B cells (NF-κB) signaling pathway is particularly relevant in the intestine, as it seems to play a dual role. Wh...

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Detalles Bibliográficos
Autores principales: Daghero, Hellen, Doffe, Flora, Varela, Belén, Yozzi, Victoria, Verdes, José Manuel, Crispo, Martina, Bollati-Fogolín, Mariela, Pagotto, Romina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829906/
https://www.ncbi.nlm.nih.gov/pubmed/36002565
http://dx.doi.org/10.1038/s41598-022-18556-3