CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model

Microglia are central to pathogenesis in many neurological conditions. Drugs targeting colony-stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical disease models have shown mixed outcomes, thus the therapeutic potential of this approach remains unclear. Here, we sho...

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Detalles Bibliográficos
Autores principales: Johnson, Noah R., Yuan, Peng, Castillo, Erika, Lopez, T. Peter, Yue, Weizhou, Bond, Annalise, Rivera, Brianna M., Sullivan, Miranda C., Hirouchi, Masakazu, Giles, Kurt, Aoyagi, Atsushi, Condello, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829908/
https://www.ncbi.nlm.nih.gov/pubmed/36624100
http://dx.doi.org/10.1038/s41467-022-35753-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829908/
https://www.ncbi.nlm.nih.gov/pubmed/36624100
http://dx.doi.org/10.1038/s41467-022-35753-w

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