CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model

Microglia are central to pathogenesis in many neurological conditions. Drugs targeting colony-stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical disease models have shown mixed outcomes, thus the therapeutic potential of this approach remains unclear. Here, we sho...

Descripción completa

Detalles Bibliográficos
Autores principales: Johnson, Noah R., Yuan, Peng, Castillo, Erika, Lopez, T. Peter, Yue, Weizhou, Bond, Annalise, Rivera, Brianna M., Sullivan, Miranda C., Hirouchi, Masakazu, Giles, Kurt, Aoyagi, Atsushi, Condello, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829908/
https://www.ncbi.nlm.nih.gov/pubmed/36624100
http://dx.doi.org/10.1038/s41467-022-35753-w

Ejemplares similares

Ejemplares similares