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In-silico design and evaluation of an epitope-based serotype-independent promising vaccine candidate for highly cross-reactive regions of pneumococcal surface protein A

BACKGROUND: The pathogenicity of pneumococcus with high morbidity, mortality, and multi-drug resistance patterns has been increasing. The limited coverage of the licensed polysaccharide-based vaccines and the replacement of the non-vaccine serotypes are the main reasons for producing a successful se...

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Detalles Bibliográficos
Autores principales: Afshari, Elnaz, Cohan, Reza Ahangari, Sotoodehnejadnematalahi, Fattah, Mousavi, Seyed Fazlollah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830136/
https://www.ncbi.nlm.nih.gov/pubmed/36627666
http://dx.doi.org/10.1186/s12967-022-03864-z