Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis

Patients with pulmonary graft-versus-host disease (pGVHD) have a poor prognosis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, pGVHD pathogenesis is not fully elucidated in humans, and currently available immunosuppressants are inadequately effective. We performed...

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Detalles Bibliográficos
Autores principales: Muranushi, Hiroyuki, Shindo, Takero, Chen-Yoshikawa, Toyofumi F, Yoshizawa, Akihiko, Thi Ngo, Huong, Gochi, Fumiaki, Date, Hiroshi, Takaori-Kondo, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830178/
https://www.ncbi.nlm.nih.gov/pubmed/35468620
http://dx.doi.org/10.1182/bloodadvances.2021006678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830178/
https://www.ncbi.nlm.nih.gov/pubmed/35468620
http://dx.doi.org/10.1182/bloodadvances.2021006678

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