A splicing-dependent ER retention signal regulates surface expression of the mechanosensitive TMEM63B cation channel

TMEM63B is a mechanosensitive cation channel activated by hypoosmotic stress and mechanic stimulation. We recently reported a brain-specific alternative splicing of exon 4 in TMEM63B. The short variant lacking exon 4, which constitutes the major isoform in the brain, exhibits enhanced responses to h...

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Detalles Bibliográficos
Autores principales: Wu, Dan, Xu, Lushan, Cai, Wen-Min, Zhan, Shi-Yu, Wan, Guoqiang, Xu, Yun, Shi, Yun Stone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830214/
https://www.ncbi.nlm.nih.gov/pubmed/36496074
http://dx.doi.org/10.1016/j.jbc.2022.102781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830214/
https://www.ncbi.nlm.nih.gov/pubmed/36496074
http://dx.doi.org/10.1016/j.jbc.2022.102781

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