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A splicing-dependent ER retention signal regulates surface expression of the mechanosensitive TMEM63B cation channel
TMEM63B is a mechanosensitive cation channel activated by hypoosmotic stress and mechanic stimulation. We recently reported a brain-specific alternative splicing of exon 4 in TMEM63B. The short variant lacking exon 4, which constitutes the major isoform in the brain, exhibits enhanced responses to h...
Autores principales: | Wu, Dan, Xu, Lushan, Cai, Wen-Min, Zhan, Shi-Yu, Wan, Guoqiang, Xu, Yun, Shi, Yun Stone |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830214/ https://www.ncbi.nlm.nih.gov/pubmed/36496074 http://dx.doi.org/10.1016/j.jbc.2022.102781 |
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