Calmodulin variant E140G associated with long QT syndrome impairs CaMKIIδ autophosphorylation and L-type calcium channel inactivation

Long QT syndrome (LQTS) is a human inherited heart condition that can cause life-threatening arrhythmia including sudden cardiac death. Mutations in the ubiquitous Ca(2+)-sensing protein calmodulin (CaM) are associated with LQTS, but the molecular mechanism by which these mutations lead to irregular...

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Detalles Bibliográficos
Autores principales: Prakash, Ohm, Gupta, Nitika, Milburn, Amy, McCormick, Liam, Deugi, Vishvangi, Fisch, Pauline, Wyles, Jacob, Thomas, N Lowri, Antonyuk, Svetlana, Dart, Caroline, Helassa, Nordine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830374/
https://www.ncbi.nlm.nih.gov/pubmed/36496072
http://dx.doi.org/10.1016/j.jbc.2022.102777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830374/
https://www.ncbi.nlm.nih.gov/pubmed/36496072
http://dx.doi.org/10.1016/j.jbc.2022.102777

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