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SIRT3 mediates the effects of PCSK9 inhibitors on inflammation, autophagy, and oxidative stress in endothelial cells

Background: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors (i) are a class of lipid-lowering drugs suggested to hold a plethora of beneficial effects independent of their LDL cholesterol-lowering properties. However, the mechanism underlying such observations is debated. Methods: H...

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Detalles Bibliográficos
Autores principales: D'Onofrio, Nunzia, Prattichizzo, Francesco, Marfella, Raffaele, Sardu, Celestino, Martino, Elisa, Scisciola, Lucia, Marfella, Lorenza, Grotta, Rosalba La, Frigé, Chiara, Paolisso, Giuseppe, Ceriello, Antonio, Balestrieri, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830434/
https://www.ncbi.nlm.nih.gov/pubmed/36632236
http://dx.doi.org/10.7150/thno.80289