Cargando…

SIRT3 mediates the effects of PCSK9 inhibitors on inflammation, autophagy, and oxidative stress in endothelial cells

Background: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors (i) are a class of lipid-lowering drugs suggested to hold a plethora of beneficial effects independent of their LDL cholesterol-lowering properties. However, the mechanism underlying such observations is debated. Methods: H...

Descripción completa

Detalles Bibliográficos
Autores principales:	D'Onofrio, Nunzia, Prattichizzo, Francesco, Marfella, Raffaele, Sardu, Celestino, Martino, Elisa, Scisciola, Lucia, Marfella, Lorenza, Grotta, Rosalba La, Frigé, Chiara, Paolisso, Giuseppe, Ceriello, Antonio, Balestrieri, Maria Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830434/ https://www.ncbi.nlm.nih.gov/pubmed/36632236 http://dx.doi.org/10.7150/thno.80289

Ejemplares similares

Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes
por: Marfella, Raffaele, et al.
Publicado: (2022)

MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4
por: Martino, Elisa, et al.
Publicado: (2023)

Effect of Hyperglycemia on COVID-19 Outcomes: Vaccination Efficacy, Disease Severity, and Molecular Mechanisms
por: Sardu, Celestino, et al.
Publicado: (2022)

Milk Exosomal miR-27b Worsen Endoplasmic Reticulum Stress Mediated Colorectal Cancer Cell Death
por: Martino, Elisa, et al.
Publicado: (2022)

SGLT-2 inhibitors and in-stent restenosis-related events after acute myocardial infarction: an observational study in patients with type 2 diabetes
por: Marfella, Raffaele, et al.
Publicado: (2023)

Hyperglycaemia on admission to hospital and COVID-19
por: Sardu, Celestino, et al.
Publicado: (2020)

Outcomes in Patients With Hyperglycemia Affected by COVID-19: Can We Do More on Glycemic Control?
por: Sardu, Celestino, et al.
Publicado: (2020)

Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients
por: D’Onofrio, Nunzia, et al.
Publicado: (2019)

Pericoronary fat inflammation and Major Adverse Cardiac Events (MACE) in prediabetic patients with acute myocardial infarction: effects of metformin
por: Sardu, Celestino, et al.
Publicado: (2019)

Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?
por: Fontanella, Rosaria Anna, et al.
Publicado: (2021)

Impact of diabetes mellitus on clinical outcomes in patients affected by Covid-19
por: Sardu, Celestino, et al.
Publicado: (2020)

Evidence for human diabetic cardiomyopathy
por: Marfella, Raffaele, et al.
Publicado: (2021)

Metformin Therapy Effects on the Expression of Sodium-Glucose Cotransporter 2, Leptin, and SIRT6 Levels in Pericoronary Fat Excised from Pre-Diabetic Patients with Acute Myocardial Infarction
por: Sardu, Celestino, et al.
Publicado: (2021)

Inflammatory Cytokines and SIRT1 Levels in Subcutaneous Abdominal Fat: Relationship With Cardiac Performance in Overweight Pre-diabetics Patients
por: Sardu, Celestino, et al.
Publicado: (2018)

Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes
por: Sardu, Celestino, et al.
Publicado: (2016)

Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques: Effects of sodium-glucose co-transporter2 inhibitor treatment
por: D'Onofrio, Nunzia, et al.
Publicado: (2021)

Could Anti‐Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID‐19 Infection? Data From Centers of Southern Italy
por: Sardu, Celestino, et al.
Publicado: (2020)

Glycated ACE2 reduces anti-remodeling effects of renin-angiotensin system inhibition in human diabetic hearts
por: Marfella, Raffaele, et al.
Publicado: (2022)

Atherosclerotic Plaque Fissuration and Clinical Outcomes in Pre-Diabetics vs. Normoglycemics Patients Affected by Asymptomatic Significant Carotid Artery Stenosis at 2 Years of Follow-Up: Role of microRNAs Modulation: The ATIMIR Study
por: Sardu, Celestino, et al.
Publicado: (2021)

SARS-COV-2 colonizes coronary thrombus and impairs heart microcirculation bed in asymptomatic SARS-CoV-2 positive subjects with acute myocardial infarction
por: Marfella, Raffaele, et al.
Publicado: (2021)

COVID-19 and Its Cardiovascular Effects: Risk Factors, Prevention and Management
por: Sardu, Celestino, et al.
Publicado: (2023)

miR-21 in Human Cardiomyopathies
por: Surina,, et al.
Publicado: (2021)

Corrigendum: miR-21 in Human Cardiomyopathies
por: Surina,, et al.
Publicado: (2022)

Awaking Blood Pressure Surge and Progression to Microalbuminuria in Type 2 Normotensive Diabetic Patients
por: Barbieri, Michelangela, et al.
Publicado: (2016)

Cardiac electrophysiological alterations and clinical response in cardiac resynchronization therapy with a defibrillator treated patients affected by metabolic syndrome
por: Sardu, Celestino, et al.
Publicado: (2017)

SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells
por: D’Onofrio, Nunzia, et al.
Publicado: (2021)

Cardiac resynchronization therapy and its effects in patients with type 2 DIAbetes mellitus OPTimized in automatic vs. echo guided approach. Data from the DIA-OPTA investigators
por: Sardu, Celestino, et al.
Publicado: (2020)

Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
por: D’Onofrio, Nunzia, et al.
Publicado: (2021)

Endothelial Dysfunction Drives CRTd Outcome at 1-Year Follow-Up: A Novel Role as Biomarker for miR-130a-5p
por: Sardu, Celestino, et al.
Publicado: (2023)

Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular Mechanisms
por: La Grotta, Rosalba, et al.
Publicado: (2022)

Multipolar pacing by cardiac resynchronization therapy with a defibrillators treatment in type 2 diabetes mellitus failing heart patients: impact on responders rate, and clinical outcomes
por: Sardu, Celestino, et al.
Publicado: (2017)

SIRT3 Modulates Endothelial Mitochondrial Redox State during Insulin Resistance
por: Martino, Elisa, et al.
Publicado: (2022)

Implications of ABO blood group in hypertensive patients with covid-19
por: Sardu, Celestino, et al.
Publicado: (2020)

Implications of AB0 blood group in hypertensive patients with covid-19
por: Sardu, Celestino, et al.
Publicado: (2020)

ELectrophysiological mechanisms underlying the Inhibitory CArdiac syncope without asystolic significant pause: Therapeutic and prognostic implications. The ELICA randomized trial
por: Sardu, Celestino, et al.
Publicado: (2018)

Does poor glycaemic control affect the immunogenicity of the COVID‐19 vaccination in patients with type 2 diabetes: The CAVEAT study
por: Marfella, Raffaele, et al.
Publicado: (2021)

Effects of incretin treatment on cardiovascular outcomes in diabetic STEMI-patients with culprit obstructive and multivessel non obstructive-coronary-stenosis
por: Marfella, Raffaele, et al.
Publicado: (2018)

Cardiac resynchronization therapy with a defibrillator (CRTd) in failing heart patients with type 2 diabetes mellitus and treated by glucagon-like peptide 1 receptor agonists (GLP-1 RA) therapy vs. conventional hypoglycemic drugs: arrhythmic burden, hospitalizations for heart failure, and CRTd responders rate
por: Sardu, Celestino, et al.
Publicado: (2018)

Serum adiponectin levels are associated with worse cognitive function in postmenopausal women
por: De Franciscis, Pasquale, et al.
Publicado: (2017)

Stretch, Injury and Inflammation Markers Evaluation to Predict Clinical Outcomes After Implantable Cardioverter Defibrillator Therapy in Heart Failure Patients With Metabolic Syndrome
por: Sardu, Celestino, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_uh1odhsu14brnaitu89neam18d