Neddylation of HER2 Inhibits its Protein Degradation and promotes Breast Cancer Progression

HER2 is a transmembrane receptor with intrinsic tyrosine kinase activity that is overexpressed in almost 25% of human breast cancers. Here, we report that the neddylation of HER2 is a new post-translational modification that controls its expression and oncogenic activity in human breast cancer. Two...

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Detalles Bibliográficos
Autores principales: Xia, Xiaohong, Hu, Tumei, He, Xiaoyue, Liu, Yuan, Yu, Cuifu, Kong, Weiyao, Liao, Yuning, Tang, Daolin, Liu, Jinbao, Huang, Hongbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830515/
https://www.ncbi.nlm.nih.gov/pubmed/36632463
http://dx.doi.org/10.7150/ijbs.75852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830515/
https://www.ncbi.nlm.nih.gov/pubmed/36632463
http://dx.doi.org/10.7150/ijbs.75852

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