Cargando…

Aspergillus Niger thermostable Cytosine deaminase-dextran conjugates with enhanced structure stability, proteolytic resistance, and Antiproliferative activity

Cytosine deaminase (CDA) is a prodrug mediating enzyme converting 5-flurocytosine into 5-flurouracil with profound broad-range anticancer activity towards various cell lines. Availability, molecular stability, and catalytic efficiency are the main limiting factors halting the clinical applications o...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Sayed, Ashraf S. A., Rady, Amgad M., Mohamed, Hossam Taha, Zein, Nabila, Yassin, Marwa A., Mohamed, Nabil Z., Hassan, Abdallah, Amer, Mahmoud M., El-Sharakawy, Reyad, El-Sharkawy, Aya Ali, El-Sayed, Nesma, Ali, Mostafa G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830863/ https://www.ncbi.nlm.nih.gov/pubmed/36627557 http://dx.doi.org/10.1186/s12866-023-02754-8

Ejemplares similares

Microbial cytosine deaminase is a programmable anticancer prodrug mediating enzyme: antibody, and gene directed enzyme prodrug therapy
por: El-Sayed, Ashraf S.A., et al.
Publicado: (2022)

Production and immobilization of β-glucanase from Aspergillus niger with its applications in bioethanol production and biocontrol of phytopathogenic fungi
por: El-Shora, Hamed M., et al.
Publicado: (2021)

Exploiting the Biosynthetic Potency of Taxol from Fungal Endophytes of Conifers Plants; Genome Mining and Metabolic Manipulation
por: El-Sayed, Ashraf S.A., et al.
Publicado: (2020)

Neoadjuvant Chemotherapy With Capecitabine Plus Cisplatin in Patients With Locally Advanced Nasopharyngeal Cancer: Case Series Study
por: Dada, Reyad, et al.
Publicado: (2016)

Unveiling antibacterial and antioxidant activities of zinc phosphate-based nanosheets synthesized by Aspergillus fumigatus and its application in sustainable decolorization of textile wastewater
por: El-Sharkawy, Reyad M., et al.
Publicado: (2023)

Inflammatory Breast Cancer: The Secretome of HCMV(+) Tumor-Associated Macrophages Enhances Proliferation, Invasion, Colony Formation, and Expression of Cancer Stem Cell Markers
por: Mohamed, Hossam Taha, et al.
Publicado: (2022)

AID/APOBEC cytosine deaminase induces genome-wide kataegis
por: Lada, Artem G, et al.
Publicado: (2012)

Statistical factorial designs for optimum production of thermostable α-amylase by the degradative bacterium Parageobacillus thermoglucosidasius Pharon1 isolated from Sinai, Egypt
por: Saeed, Ali M., et al.
Publicado: (2021)

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
por: Nabel, Christopher S., et al.
Publicado: (2012)

Improved cytotoxic effects of Salmonella-producing cytosine deaminase in tumour cells
por: Mesa-Pereira, Beatriz, et al.
Publicado: (2015)

Directed evolution of Aspergillus niger glucoamylase to increase thermostability
por: McDaniel, Allison, et al.
Publicado: (2008)

Green method for improving performance attributes of wool fibres using immobilized proteolytic thermozyme
por: Gomaa, Sanaa K., et al.
Publicado: (2022)

Flavone Biotransformation by Aspergillus niger and the Characterization of Two Newly Formed Metabolites
por: Mahmoud, Yehia A. G., et al.
Publicado: (2008)

Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
por: Dubois, L, et al.
Publicado: (2007)

The association between circulating MicroRNA‐150 level and cholangiocarcinoma
por: Salem, Perihan El Sayed, et al.
Publicado: (2020)

Production of Proteolytic Enzymes by a Keratin-Degrading Aspergillus niger
por: Lopes, Fernanda Cortez, et al.
Publicado: (2011)

Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs
por: Vande Voorde, Johan, et al.
Publicado: (2015)

Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B
por: Shi, Ke, et al.
Publicado: (2017)

The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS
por: Niocel, Mathilde, et al.
Publicado: (2019)

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
por: Grünewald, Julian, et al.
Publicado: (2020)

Engineering the Active Site Lid Dynamics to Improve the Catalytic Efficiency of Yeast Cytosine Deaminase
por: Deng, Hanzhong, et al.
Publicado: (2023)

RETRACTED ARTICLE: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a
por: Halawany, Ali M. El, et al.
Publicado: (2017)

Retraction Note: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a
por: El Halawany, Ali M., et al.
Publicado: (2023)

Immunomodulatory Effect of Vitamin C on Proinflammatory Cytokines Production in Ossimi Lambs (Ovis aries) with Pneumonic Pasteurellosis
por: Rizk, Mohamed Abdo, et al.
Publicado: (2021)

Isolation, molecular identification of lipid-producing Rhodotorula diobovata: optimization of lipid accumulation for biodiesel production
por: Osman, Mohamed E., et al.
Publicado: (2022)

Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways
por: El-Sahar, Ayman E, et al.
Publicado: (2020)

Purification and Characterization of Ornithine Decarboxylase from Aspergillus terreus; Kinetics of Inhibition by Various Inhibitors
por: El-Sayed, Ashraf S.A., et al.
Publicado: (2019)

The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients
por: Ali, Magdi A., et al.
Publicado: (2023)

Transcatheter Atrial Septal Defect Closure Before Versus After Adulthood
por: Hafez, Mohamed S., et al.
Publicado: (2022)

Biodiesel Production by Aspergillus niger Lipase Immobilized on Barium Ferrite Magnetic Nanoparticles
por: El-Batal, Ahmed I., et al.
Publicado: (2016)

Assessment of Canadian Syncope Risk Score in the prediction of outcomes of patients with syncope at the Emergency Department of Suez Canal University: STROBE compliant
por: Moussa, Bassant Sayed, et al.
Publicado: (2022)

Aspergillus tamarii mediated green synthesis of magnetic chitosan beads for sustainable remediation of wastewater contaminants
por: El-Sharkawy, Reyad M., et al.
Publicado: (2022)

Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazoline, 1,3-Thiazolidine, and 1,2,4-Triazoline Double-Tailed Acyclo C-Nucleosides
por: Nasr, Adel Z., et al.
Publicado: (2022)

Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts
por: Liu, J, et al.
Publicado: (2007)

Retrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells
por: Sung Park, Jin, et al.
Publicado: (2013)

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B
por: Akre, Monica K., et al.
Publicado: (2016)

Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers
por: Ding, Yuedi, et al.
Publicado: (2020)

Gene Therapy with Cytosine Deaminase and Endostatin Fusion Gene Mediated by Endothelial Progenitor Cells in Hepatomas
por: Zhang, Yue-Lin, et al.
Publicado: (2020)

APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A
por: Wong, Lai, et al.
Publicado: (2020)

Cytosine and adenine deaminase base-editors induce broad and nonspecific changes in gene expression and splicing
por: Fan, Jiao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9tu8v3kcgeqj1ct8q3m9ap3rn6