Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells

BACKGROUND: Our previous study demonstrated that M1 macrophages could impair tight junctions (TJs) between vascular endothelial cells by secreting interleukin-6 (IL-6) after spinal cord injury (SCI). Tocilizumab, as a humanized IL-6 receptor (IL-6R) monoclonal antibody approved for the clinic, has b...

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Detalles Bibliográficos
Autores principales: Luo, Yang, Yao, Fei, Shi, Yi, Zhu, Zhenyu, Xiao, Zhaoming, You, Xingyu, Liu, Yanchang, Yu, Shuisheng, Tian, Dasheng, Cheng, Li, Zheng, Meige, Jing, Juehua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830903/
https://www.ncbi.nlm.nih.gov/pubmed/36624478
http://dx.doi.org/10.1186/s12987-022-00399-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830903/
https://www.ncbi.nlm.nih.gov/pubmed/36624478
http://dx.doi.org/10.1186/s12987-022-00399-9

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