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A strategy for evaluating potential antiviral resistance to small molecule drugs and application to SARS-CoV-2
Alterations in viral fitness cannot be inferred from only mutagenesis studies of an isolated viral protein. To-date, no systematic analysis has been performed to identify mutations that improve virus fitness and reduce drug efficacy. We present a generic strategy to evaluate which viral mutations mi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831016/ https://www.ncbi.nlm.nih.gov/pubmed/36627366 http://dx.doi.org/10.1038/s41598-023-27649-6 |