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The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients

BACKGROUND: Patients with inflammatory bowel disease (IBD) treated with anti-TNF therapy exhibit attenuated humoral immune responses to vaccination against SARS-CoV-2. The gut microbiota and its functional metabolic output, which are perturbed in IBD, play an important role in shaping host immune re...

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Detalles Bibliográficos
Autores principales: Alexander, James L., Mullish, Benjamin H., Danckert, Nathan P., Liu, Zhigang, Olbei, Marton L., Saifuddin, Aamir, Torkizadeh, Melissa, Ibraheim, Hajir, Blanco, Jesús Miguéns, Roberts, Lauren A., Bewshea, Claire M., Nice, Rachel, Lin, Simeng, Prabhudev, Hemanth, Sands, Caroline, Horneffer-van der Sluis, Verena, Lewis, Matthew, Sebastian, Shaji, Lees, Charlie W., Teare, Julian P., Hart, Ailsa, Goodhand, James R., Kennedy, Nicholas A., Korcsmaros, Tamas, Marchesi, Julian R., Ahmad, Tariq, Powell, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831064/
https://www.ncbi.nlm.nih.gov/pubmed/36634565
http://dx.doi.org/10.1016/j.ebiom.2022.104430