Solid-phase synthesis and pathological evaluation of pyroglutamate amyloid-β(3-42) peptide

Pyroglutamate amyloid-β(3-42) (Aβ(pE3-42)) is an N-terminally truncated and pyroglutamate-modified Aβ peptide retaining highly hydrophobic, amyloidogenic, and neurotoxic properties. In Alzheimer’s disease (AD) patients, Aβ(pE3-42) peptides accumulate into oligomers and induce cellular toxicity and s...

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Detalles Bibliográficos
Autores principales: Cho, Illhwan, Lee, HeeYang, Lee, Donghee, Park, In Wook, Yoon, Soljee, Kim, Hye Yun, Kim, YoungSoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831997/
https://www.ncbi.nlm.nih.gov/pubmed/36627316
http://dx.doi.org/10.1038/s41598-022-26616-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831997/
https://www.ncbi.nlm.nih.gov/pubmed/36627316
http://dx.doi.org/10.1038/s41598-022-26616-x

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