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Nanoformulation of the K-Ras(G12D)-inhibitory peptide KS-58 suppresses colorectal and pancreatic cancer-derived tumors

Single amino acid mutations of Ras occur in 30% of human cancers. In particular, K-Ras(G12D) has been detected in the majority of intractable colorectal and pancreatic cancers. Although efforts to target K-Ras(G12D) are currently underway, no effective drugs are available. We previously found that t...

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Detalles Bibliográficos
Autores principales: Sakamoto, Kotaro, Qi, Yun, Miyako, Eijiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832047/
https://www.ncbi.nlm.nih.gov/pubmed/36627374
http://dx.doi.org/10.1038/s41598-023-27825-8