Regulation of insulin secretion in mouse islets: metabolic amplification by alpha-ketoisocaproate coincides with rapid and sustained increase in acetyl-CoA content

Glucose and alpha-ketoisocaproate, the keto acid analogue of leucine, stimulate insulin secretion in the absence of other exogenous fuels. Their mitochondrial metabolism in the beta-cell raises the cytosolic ATP/ADP ratio, thereby providing the triggering signal for the exocytosis of the insulin gra...

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Detalles Bibliográficos
Autores principales: Panten, Uwe, Brüning, Dennis, Rustenbeck, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832085/
https://www.ncbi.nlm.nih.gov/pubmed/36355207
http://dx.doi.org/10.1007/s00210-022-02290-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832085/
https://www.ncbi.nlm.nih.gov/pubmed/36355207
http://dx.doi.org/10.1007/s00210-022-02290-8

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