CAR-tropic extracellular vesicles carry tumor-associated antigens and modulate CAR T cell functionality

Tumor-derived extracellular vesicles (EVs) are active contributors in metastasis and immunosuppression in tumor microenvironment. At least some of the EVs carry tumor surface molecules such as tumor-associated antigens (TAAs) and/or checkpoint inhibitors, and potentially could interact with T cells...

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Detalles Bibliográficos
Autores principales: Ukrainskaya, V. M., Musatova, O. E., Volkov, D. V., Osipova, D. S., Pershin, D. S., Moysenovich, A. M., Evtushenko, E. G., Kulakovskaya, E. A., Maksimov, E. G., Zhang, H., Rubtsov, Y. P., Maschan, M. A., Stepanov, A. V., Gabibov, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832131/
https://www.ncbi.nlm.nih.gov/pubmed/36627334
http://dx.doi.org/10.1038/s41598-023-27604-5

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