CYP2C19 Plays a Major Role in the Hepatic N-Oxidation of Cotinine

The primary mode of metabolism of nicotine is via the formation of cotinine by the enzyme CYP2A6. Cotinine undergoes further CYP2A6-mediated metabolism by hydroxylation to 3-hydroxycotinine and norcotinine, but can also form cotinine-N-glucuronide and cotinine-N-oxide (COX). The goal of this study w...

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Detalles Bibliográficos
Autores principales: Perez-Paramo, Yadira X., Watson, Christy J.W., Chen, Gang, Lazarus, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832378/
https://www.ncbi.nlm.nih.gov/pubmed/35197312
http://dx.doi.org/10.1124/dmd.121.000624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832378/
https://www.ncbi.nlm.nih.gov/pubmed/35197312
http://dx.doi.org/10.1124/dmd.121.000624

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