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CYP2C19 Plays a Major Role in the Hepatic N-Oxidation of Cotinine

The primary mode of metabolism of nicotine is via the formation of cotinine by the enzyme CYP2A6. Cotinine undergoes further CYP2A6-mediated metabolism by hydroxylation to 3-hydroxycotinine and norcotinine, but can also form cotinine-N-glucuronide and cotinine-N-oxide (COX). The goal of this study w...

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Detalles Bibliográficos
Autores principales:	Perez-Paramo, Yadira X., Watson, Christy J.W., Chen, Gang, Lazarus, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832378/ https://www.ncbi.nlm.nih.gov/pubmed/35197312 http://dx.doi.org/10.1124/dmd.121.000624

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