A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration

Age-related macular degeneration (AMD) is linked to 2 main disparate genetic pathways: a chromosome 10 risk locus and the alternative pathway (AP) of complement. Rare genetic variants in complement factor H (CFH; FH) and factor I (CFI; FI) are associated with AMD. FH acts as a soluble cofactor to fa...

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Detalles Bibliográficos
Autores principales: Hallam, Thomas M., Cox, Thomas E., Smith-Jackson, Kate, Brocklebank, Vicky, Baral, April J., Tzoumas, Nikolaos, Steel, David H., Wong, Edwin K. S., Shuttleworth, Victoria G., Lotery, Andrew J., Harris, Claire L., Marchbank, Kevin J., Kavanagh, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832388/
https://www.ncbi.nlm.nih.gov/pubmed/36643920
http://dx.doi.org/10.3389/fimmu.2022.1028760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832388/
https://www.ncbi.nlm.nih.gov/pubmed/36643920
http://dx.doi.org/10.3389/fimmu.2022.1028760

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