DNA fragility at the KMT2A/MLL locus: insights from old and new technologies

The Mixed-Lineage Leukaemia (MLL/KMT2A) gene is frequently rearranged in childhood and adult acute leukaemia (AL) and in secondary leukaemias occurring after therapy with DNA topoisomerase targeting anti-cancer agents such as etoposide (t-AL). MLL/KMT2A chromosome translocation break sites in AL pat...

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Detalles Bibliográficos
Autores principales: Cowell, Ian G., Austin, Caroline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832561/
https://www.ncbi.nlm.nih.gov/pubmed/36629017
http://dx.doi.org/10.1098/rsob.220232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832561/
https://www.ncbi.nlm.nih.gov/pubmed/36629017
http://dx.doi.org/10.1098/rsob.220232

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