Cargando…

TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts

BACKGROUND: Lung fibroblast activation is associated with airway remodeling during asthma progression. Stearoyl-CoA desaturase 1 (SCD1) plays an important role in the response of fibroblasts to growth factors. This study aimed to explore the effects of SCD1 on fibroblast activation induced by transf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Zili, Liang, Shixiu, Zhou, Zicong, Liu, Jieyi, Zhang, Jinming, Meng, Xiaojing, Zou, Fei, Zhao, Haijin, Yu, Changhui, Cai, Shaoxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832654/ https://www.ncbi.nlm.nih.gov/pubmed/36627645 http://dx.doi.org/10.1186/s12931-023-02313-9

Ejemplares similares

Avasimibe Alleviates Disruption of the Airway Epithelial Barrier by Suppressing the Wnt/β-Catenin Signaling Pathway
por: Zhou, Zicong, et al.
Publicado: (2022)

House dust mite disrupts the airway epithelial barrier by affecting the expression of thymic stromal lymphopoietin through inducing Atg5
por: Zhou, Zicong, et al.
Publicado: (2023)

Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin
por: Yu, Changhui, et al.
Publicado: (2022)

Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutatnt colorectal cancer
por: Chen, Hao, et al.
Publicado: (2022)

TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway
por: Yin, F, et al.
Publicado: (2017)

Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway
por: Zhou, Jian, et al.
Publicado: (2019)

Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway
por: Hu, Jie, et al.
Publicado: (2019)

SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1β pathway: SREBP2 Inhibitor sensitizes HCC to lenvatinib
por: Fan, Minghao, et al.
Publicado: (2023)

Orai3 mediates Orai channel remodelling to activate fibroblast in pulmonary fibrosis
por: Yu, Changhui, et al.
Publicado: (2022)

Expression of TGF-β1/mTOR signaling pathway in pathological scar fibroblasts
por: Zhai, Xiao-Xiang, et al.
Publicado: (2017)

Xanthohumol Inhibits TGF-β1-Induced Cardiac Fibroblasts Activation via Mediating PTEN/Akt/mTOR Signaling Pathway
por: Jiang, Chuanhao, et al.
Publicado: (2020)

Akt1 Enhances CA916798 Expression through mTOR Pathway
por: Wang, Yu-Liang, et al.
Publicado: (2013)

Th-POK regulates mammary gland lactation through mTOR-SREBP pathway
por: Zhang, Rui, et al.
Publicado: (2018)

LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells
por: Zhou, Youping, et al.
Publicado: (2018)

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity
por: Carobbio, Stefania, et al.
Publicado: (2013)

Bee Venom and Its Major Component Melittin Attenuated Cutibacterium acnes- and IGF-1-Induced Acne Vulgaris via Inactivation of Akt/mTOR/SREBP Signaling Pathway
por: Gu, Hyemin, et al.
Publicado: (2022)

MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors: MEN1 promotes ferroptosis in pancreatic neuroendocrine tumors
por: Ye, Zeng, et al.
Publicado: (2022)

ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway
por: Liu, Wenting, et al.
Publicado: (2022)

RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
por: Wang, Guangchuan, et al.
Publicado: (2019)

TGF-β1 promotes the osteoinduction of human osteoblasts via the PI3K/AKT/mTOR/S6K1 signalling pathway
por: Zhang, Zhaodong, et al.
Publicado: (2019)

EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling
por: Cheng, Dong-dong, et al.
Publicado: (2018)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy
por: Sokolosky, Melissa L., et al.
Publicado: (2011)

SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway
por: Xu, Hao, et al.
Publicado: (2018)

Plumbagin attenuates traumatic tracheal stenosis in rats and inhibits lung fibroblast proliferation and differentiation via TGF-β1/Smad and Akt/mTOR pathways
por: Shi, Wei, et al.
Publicado: (2021)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis
por: Triki, Mouna, et al.
Publicado: (2020)

Effect of the Notch1-mediated PI3K-Akt-mTOR pathway in human osteosarcoma
por: Zhang, Kexiang, et al.
Publicado: (2021)

SPI1 involvement in malignant melanoma pathogenesis by regulation of HK2 through the AKT1/mTOR pathway
por: Liu, Chunlei, et al.
Publicado: (2023)

HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter
por: Yang, Xueliang, et al.
Publicado: (2018)

Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis
por: Zhao, Jia-Xing, et al.
Publicado: (2017)

Receptor for activated C kinase 1 (RACK1) promotes the progression of OSCC via the AKT/mTOR pathway
por: Zhang, Xuefeng, et al.
Publicado: (2022)

MC-LR Aggravates Liver Lipid Metabolism Disorders in Obese Mice Fed a High-Fat Diet via PI3K/AKT/mTOR/SREBP1 Signaling Pathway
por: Chu, Hanyu, et al.
Publicado: (2022)

Down-Regulation of SREBP via PI3K/AKT/mTOR Pathway Inhibits the Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells
por: Zhang, Bo, et al.
Publicado: (2020)

Effects of Syringic Acid on Apoptosis, Inflammation, and AKT/mTOR Signaling Pathway in Gastric Cancer Cells
por: Pei, Jinjin, et al.
Publicado: (2021)

α-Tocopherol-13′-Carboxychromanol Induces Cell Cycle Arrest and Cell Death by Inhibiting the SREBP1-SCD1 Axis and Causing Imbalance in Lipid Desaturation
por: Liao, Sijia, et al.
Publicado: (2023)

Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis
por: Liu, Yuanyuan, et al.
Publicado: (2021)

SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice
por: Li, Lei, et al.
Publicado: (2013)

Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF‐beta and AKT/mTOR signaling pathways
por: Shijie, Li, et al.
Publicado: (2021)

TDRG1 functions in testicular seminoma are dependent on the PI3K/Akt/mTOR signaling pathway
por: Wang, Yong, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ug6neipreehu9l7hsl1g9bn8gc