Cargando…

Global insights into the fine tuning of human A(2A)AR conformational dynamics in a ternary complex with an engineered G protein viewed by NMR

G protein-coupled receptor (GPCR) conformational plasticity enables formation of ternary signaling complexes with intracellular proteins in response to binding extracellular ligands. We investigate the dynamic process of GPCR complex formation in solution with the human A(2A) adenosine receptor (A(2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferré, Guillaume, Anazia, Kara, Silva, Larissa O., Thakur, Naveen, Ray, Arka P., Eddy, Matthew T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832913/ https://www.ncbi.nlm.nih.gov/pubmed/36543140 http://dx.doi.org/10.1016/j.celrep.2022.111844

Ejemplares similares

Production of human A(2A)AR in lipid nanodiscs for (19)F-NMR and single-molecule fluorescence spectroscopy
por: Thakur, Naveen, et al.
Publicado: (2022)

Controlling protein function by fine-tuning conformational flexibility
por: Schmid, Sonja, et al.
Publicado: (2020)

Production of a Human Histamine Receptor for NMR Spectroscopy in Aqueous Solutions
por: Mulry, Emma, et al.
Publicado: (2021)

Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity
por: Krauson, Aram J., et al.
Publicado: (2015)

Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions?
por: Dias, David M., et al.
Publicado: (2013)

Conformational plasticity of ligand-bound and ternary GPCR complexes studied by (19)F NMR of the β(1)-adrenergic receptor
por: Frei, J. Niclas, et al.
Publicado: (2020)

A comparative study of interfacial environments in lipid nanodiscs and vesicles
por: You, Xiao, et al.
Publicado: (2022)

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions
por: Kalas, Vasilios, et al.
Publicado: (2017)

Tuning and Fine-Tuning of Synapses with Adenosine
por: Sebastião, A.M, et al.
Publicado: (2009)

Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation
por: Wieteska, Lukasz, et al.
Publicado: (2017)

BERT’s sentiment score for portfolio optimization: a fine-tuned view in Black and Litterman model
por: Colasanto, Francesco, et al.
Publicado: (2022)

C5aR(+) dendritic cells fine-tune the Peyer’s patch microenvironment to induce antigen-specific CD8(+) T cells
por: Kim, Sae-Hae, et al.
Publicado: (2023)

Finely tuned conformational dynamics regulate the protective function of the lncRNA MALAT1 triple helix
por: Ageeli, Abeer A, et al.
Publicado: (2019)

Resilient Intracrystalline Occlusions: A Solid-State NMR View of Local Structure as It Tunes Bulk Lattice Properties
por: Ben Shir, Ira, et al.
Publicado: (2020)

On the Tuning of High-Resolution NMR Probes
por: Pöschko, Maria Theresia, et al.
Publicado: (2014)

Inner-View of Nanomaterial Incited Protein Conformational Changes: Insights into Designable Interaction
por: Mukhopadhyay, Arka, et al.
Publicado: (2018)

Single-molecule visualization of human A(2A) adenosine receptor activation by a G protein and constitutively activating mutations
por: Wei, Shushu, et al.
Publicado: (2023)

Membrane Mimetic-Dependence of GPCR Energy Landscapes
por: Thakur, Naveen, et al.
Publicado: (2023)

Analysis of β(2)AR-G(s) and β(2)AR-G(i) complex formation by NMR spectroscopy
por: Ma, Xiuyan, et al.
Publicado: (2020)

Fine-tuning helper Ts
por: Maxmen, Amy
Publicado: (2009)

The fine-tuning price of LEP
por: Chankowski, Piotr H., et al.
Publicado: (1997)

Fine-tuning in the physical universe
por: Sloan, David, et al.
Publicado: (2020)

Fine-tuning Metabolic Switches
por: Sedwick, Caitlin
Publicado: (2013)

Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes
por: Huang, Nan-Lan, et al.
Publicado: (2014)

Enhancing the FRET by tuning the bandgap of acceptor ternary ZnCdS quantum dots
por: Mubeen, Muhammad, et al.
Publicado: (2023)

Fine Structure in the $\beta$-Delayed Proton Decay of $^{33}$Ar
por: Honkanen, J A, et al.
Publicado: (1996)

Full and Partial Agonists of Thromboxane Prostanoid Receptor Unveil Fine Tuning of Receptor Superactive Conformation and G Protein Activation
por: Capra, Valérie, et al.
Publicado: (2013)

Observing enzyme ternary transition state analogue complexes by (19)F NMR spectroscopy
por: Ampaw, Anna, et al.
Publicado: (2017)

Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation()
por: Blundell, Charles D., et al.
Publicado: (2013)

On the MSSM Higgsino mass and fine tuning
por: Ross, Graham G., et al.
Publicado: (2016)

GABA fine-tunes the glycine receptor
por: Robinson, Richard
Publicado: (2008)

Fine tuning and the scale of new physics
por: Barbieri, Riccardo
Publicado: (2011)

Fine-tuning candidate therapy for RASopathies
Publicado: (2012)

Nonlocality as an explanation for fine-tuning in nature
por: Bennett, D L, et al.
Publicado: (1995)

Fine-tuning problem and the renormalization group
por: Wetterich, C
Publicado: (1984)

Workshop on Naturalness, Hierarchy, and Fine Tuning
por: Rosaler, Joshua, et al.
Publicado: (2018)

Metabolism fine-tunes macrophage activation
por: Torres, AnnMarie, et al.
Publicado: (2016)

Riboregulators: Fine-Tuning Virulence in Shigella
por: Fris, Megan E., et al.
Publicado: (2016)

Fine‐tuning PERK signaling for neuroprotection
por: Halliday, Mark, et al.
Publicado: (2017)

microRNAs: fine tuning of erythropoiesis
por: Listowski, Marcin A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_l8tv3gbfoj8lnoo3itfihl9bi4