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High-resolution cryo-EM structure of the junction region of the native cardiac thin filament in relaxed state

Cardiac contraction depends on molecular interactions among sarcomeric proteins coordinated by the rising and falling intracellular Ca(2+) levels. Cardiac thin filament (cTF) consists of two strands composed of actin, tropomyosin (Tm), and equally spaced troponin (Tn) complexes forming regulatory un...

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Detalles Bibliográficos
Autores principales: Risi, Cristina M, Belknap, Betty, White, Howard D, Dryden, Kelly, Pinto, Jose R, Chase, P Bryant, Galkin, Vitold E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832952/
https://www.ncbi.nlm.nih.gov/pubmed/36712934
http://dx.doi.org/10.1093/pnasnexus/pgac298