Designing and identifying β-hairpin peptide macrocycles with antibiotic potential

Peptide macrocycles are a rapidly emerging class of therapeutic, yet the design of their structure and activity remains challenging. This is especially true for those with β-hairpin structure due to weak folding properties and a propensity for aggregation. Here, we use proteomic analysis and common...

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Detalles Bibliográficos
Autores principales: Randall, Justin R., DuPai, Cory D., Cole, T. Jeffrey, Davidson, Gillian, Groover, Kyra E., Slater, Sabrina L., Mavridou, Despoina A. I., Wilke, Claus O., Davies, Bryan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833666/
https://www.ncbi.nlm.nih.gov/pubmed/36630516
http://dx.doi.org/10.1126/sciadv.ade0008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833666/
https://www.ncbi.nlm.nih.gov/pubmed/36630516
http://dx.doi.org/10.1126/sciadv.ade0008

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