DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

Execution of lineage-specific differentiation programs requires tight coordination between many regulators including Ten-eleven translocation (TET) family enzymes, catalyzing 5-methylcytosine oxidation in DNA. Here, by using Keratin 14–Cre–driven ablation of Tet genes in skin epithelial cells, we de...

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Detalles Bibliográficos
Autores principales: Chen, Guo-Dong, Fatima, Iqra, Xu, Qin, Rozhkova, Elena, Fessing, Michael Y., Mardaryev, Andrei N., Sharov, Andrey A., Xu, Guo-Liang, Botchkarev, Vladimir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833667/
https://www.ncbi.nlm.nih.gov/pubmed/36630508
http://dx.doi.org/10.1126/sciadv.abo7605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833667/
https://www.ncbi.nlm.nih.gov/pubmed/36630508
http://dx.doi.org/10.1126/sciadv.abo7605

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