TGFβ1(+)CCR5(+) neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice

TGFβ1 induces age-related bone loss by promoting degradation of TNF receptor-associated factor 3 (TRAF3), levels of which decrease in murine and human bone during aging. We report that a subset of neutrophils (TGFβ1(+)CCR5(+)) is the major source of TGFβ1 in murine bone. Their numbers are increased...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jinbo, Yao, Zhenqiang, Liu, Xin, Duan, Rong, Yi, Xiangjiao, Ayoub, Akram, Sanders, James O., Mesfin, Addisu, Xing, Lianping, Boyce, Brendan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834218/
https://www.ncbi.nlm.nih.gov/pubmed/36631487
http://dx.doi.org/10.1038/s41467-023-35801-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834218/
https://www.ncbi.nlm.nih.gov/pubmed/36631487
http://dx.doi.org/10.1038/s41467-023-35801-z

Ejemplares similares