TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response

TP73 is expressed as multiple N- and C-terminal isoforms through two separate promoters or alternative splicing. While N-terminal p73 isoforms have been well studied, very little is known about p73 C-terminal isoforms. Thus, CRISPR was used to delete TP73 Exon13 (E13-KO) to induce p73α to p73β isofo...

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Detalles Bibliográficos
Autores principales: Zhang, Jin, Sun, Wenqiang, Yan, Wensheng, Kong, Xiangmudong, Shen, Tong, Laubach, Kyra, Chen, Mingyi, Chen, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834251/
https://www.ncbi.nlm.nih.gov/pubmed/36631448
http://dx.doi.org/10.1038/s41419-022-05529-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834251/
https://www.ncbi.nlm.nih.gov/pubmed/36631448
http://dx.doi.org/10.1038/s41419-022-05529-7

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