Cargando…

Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

Classical cadherins, including vascular endothelial (VE)-cadherin, are targeted by matrix metalloproteinases (MMPs) and γ-secretase during adherens junction (AJ) disassembly, a mechanism that might have relevance for endothelial cell (EC) integrity and vascular homeostasis. Here, we show that oxidat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ivaldo, Caterina, Passalacqua, Mario, Furfaro, Anna Lisa, d’Abramo, Cristina, Ruiz, Santiago, Chatterjee, Prodyot K., Metz, Christine N., Nitti, Mariapaola, Marambaud, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834263/ https://www.ncbi.nlm.nih.gov/pubmed/36631513 http://dx.doi.org/10.1038/s41598-022-27308-2

Ejemplares similares

Clinical Significance of Heme Oxygenase 1 in Tumor Progression
por: Nitti, Mariapaola, et al.
Publicado: (2021)

A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10
por: Ruiz, Santiago, et al.
Publicado: (2016)

HO-1 Limits the Efficacy of Vemurafenib/PLX4032 in BRAF(V600E) Mutated Melanoma Cells Adapted to Physiological Normoxia or Hypoxia
por: Furfaro, Anna Lisa, et al.
Publicado: (2022)

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
por: Benn, Andreas, et al.
Publicado: (2016)

Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin
por: Chen, Hsien-Lin, et al.
Publicado: (2021)

Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization
por: Navarro, Pilar, et al.
Publicado: (1998)

The cytotoxicity of γ-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ-secretase inhibition
por: Han, Jianxun, et al.
Publicado: (2009)

How VE-cadherin goes with the flow
por: Short, Ben
Publicado: (2015)

microRNA-494 Favors HO-1 Expression in Neuroblastoma Cells Exposed to Oxidative Stress in a Bach1-Independent Way
por: Piras, Sabrina, et al.
Publicado: (2018)

Notch versus the proteasome: what is the target of γ-secretase inhibitor-I?
por: Clementz, Anthony G, et al.
Publicado: (2009)

N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis
por: Luo, Yang, et al.
Publicado: (2005)

Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice
por: Vitale, Francesca, et al.
Publicado: (2018)

Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models
por: Vitale, Francesca, et al.
Publicado: (2020)

Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?
por: Nitti, Mariapaola, et al.
Publicado: (2020)

Endothelial Phosphatase VE-PTP Participates in Vasculogenic Mimicry by Preventing Autophagic Degradation of VE-Cadherin
por: Delgado-Bellido, Daniel, et al.
Publicado: (2020)

Endothelial permeability and VE-cadherin: A wacky comradeship
por: Gavard, Julie
Publicado: (2014)

VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance
por: Yang, Ying, et al.
Publicado: (2019)

Differentiation impairs Bach1 dependent HO-1 activation and increases sensitivity to oxidative stress in SH-SY5Y neuroblastoma cells
por: Piras, Sabrina, et al.
Publicado: (2017)

Nicotinic Acetylcholine Receptor Agonists Attenuate Septic Acute Kidney Injury in Mice by Suppressing Inflammation and Proteasome Activity
por: Chatterjee, Prodyot K., et al.
Publicado: (2012)

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin
por: Frye, Maike, et al.
Publicado: (2015)

VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism
por: Juettner, Vanessa V., et al.
Publicado: (2019)

Endothelial barrier dysfunction in systemic inflammation is mediated by soluble VE-cadherin interfering VE-PTP signaling
por: Knop, Juna-Lisa, et al.
Publicado: (2023)

γ-secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets
por: Dorneburg, Carmen, et al.
Publicado: (2016)

VE-Cadherin–Mediated Epigenetic Regulation of Endothelial Gene Expression
por: Morini, Marco F., et al.
Publicado: (2018)

Antitumor immunity induced by VE-cadherin modified DC vaccine
por: Zhou, Jing, et al.
Publicado: (2017)

Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin
por: Duong, Cao Nguyen, et al.
Publicado: (2020)

Extracellular matrix regulates force transduction at VE-cadherin junctions
por: Kong, Xinyu, et al.
Publicado: (2022)

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF
por: Nottebaum, Astrid F., et al.
Publicado: (2008)

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo
por: Broermann, Andre, et al.
Publicado: (2011)

Intermedin promotes vessel fusion by inducing VE‐cadherin accumulation at potential fusion sites and to achieve a dynamic balance between VE‐cadherin‐complex dissociation/reconstitution
por: Kong, Lingmiao, et al.
Publicado: (2020)

Changes in expression of VE-cadherin and MMPs in endothelial cells: Implications for angiogenesis
por: Kiran, Manikantan S, et al.
Publicado: (2011)

The VE-cadherin cytoplasmic domain undergoes proteolytic processing during endocytosis
por: Su, Wenji, et al.
Publicado: (2017)

Desacetylvinblastine Monohydrazide Disrupts Tumor Vessels by Promoting VE-cadherin Internalization
por: Lei, Xueping, et al.
Publicado: (2018)

Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin
por: Delgado-Bellido, Daniel, et al.
Publicado: (2017)

VE-cadherin endocytosis controls vascular integrity and patterning during development
por: Grimsley-Myers, Cynthia M., et al.
Publicado: (2020)

GSTpi regulates VE-cadherin stabilization through promoting S-glutathionylation of Src
por: Yang, Yang, et al.
Publicado: (2019)

Novel mechanism regulating endothelial permeability via T-cadherin-dependent VE-cadherin phosphorylation and clathrin-mediated endocytosis
por: Semina, Ekaterina V., et al.
Publicado: (2013)

Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling
por: Huveneers, Stephan, et al.
Publicado: (2012)

Vitronectin Increases Vascular Permeability by Promoting VE-Cadherin Internalization at Cell Junctions
por: Li, Rong, et al.
Publicado: (2012)

Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells
por: Kim, Dae Won, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jo9r3urqj20mftd10pfof864oi